Immunomedics, Inc. Announces Results From Two Clinical Trials

Immunomedics, Inc. announced that two studies conducted by outside investigators that involved the Company's antibody drug candidates were presented. Patients in this Phase I/II study received veltuzumab at 200 mg/m2 weekly combined with escalating doses of milatuzumab at 8, 16, and 20 mg/kg twice per week of weeks 1 to 4, 12, 20, 28, and 36. Three of the first six patients enrolled at dose levels 1 and 2 had significant grade 3 infusion reactions with milatuzumab. The study was amended to separate veltuzumab and milatuzumab dosing days and to add additional premedication. No dose-limiting toxicities were then observed, and no patients experienced grade 3 infusion reactions after the protocol was modified. Human anti-veltuzumab and anti-milatuzumab antibodies, collected on day 1 of weeks 4, 12, and 36, have not been detected in any patient. The dose-escalation phase of this study has completed enrollment with 18 patients diagnosed with various types of NHL, including both indolent and aggressive forms, having received at least 4 weeks of the combination therapy. All 18 patients were assessable for response at week 5.