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Pfizer Inc announces Bococizumab (RN316) significantly reduced LDL Cholesterol in statin-treated adults with high cholesterol in A Phase 2b Study1

Thursday, 27 Mar 2014 08:00am EDT 

Pfizer Inc:Bococizumab (RN316) significantly reduced LDL Cholesterol In Statin-Treated Adults With High Cholesterol In A Phase 2b Study (1).Phase 2b results of a 24 week, randomized, placebo-controlled, dose-ranging study of investigational bococizumab, proposed generic name for RN316.Statin treated patients with high cholesterol were randomized to various doses of either bococizumab twice or once monthly subcutaneous administration or placebo.Study met its primary endpoint across all doses, showing that bococizumab significantly reduced low density lipoprotein cholesterol (LDL-C) from baseline compared to placebo in adults with high cholesterol also taking statin therapy.Percentage of patients reporting adverse events or serious adverse events was similar across placebo- and bococizumab-treatment groups.