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Merck & Co Inc Announces Interim Results From Phase II, Multi-center, Randomized, Dose-ranging Study Assessing Safety And Antiviral Activity Of MK-5172


Saturday, 10 Nov 2012 09:00am EST 

Merck & Co Inc announced interim results from a Phase II, multi-center, randomized, dose-ranging study (n=332) assessing the safety and antiviral activity of MK-5172, an investigational, once-daily, oral NS3/4A protease inhibitor for the treatment of chronic hepatitis C virus (HCV) genotype 1 infection in combination therapy in treatment-na├»ve patients. These data will be presented this week at the American Association for the Study of Liver Diseases Annual Meeting (AASLD). The primary efficacy endpoint of the study was to evaluate the complete early viral response (cEVR) of four regimens of MK-5172 in combination with peginterferon alfa-2b and ribavirin (PR) compared to the control arm in which patients received a 4-week lead-in of PR followed by the addition of VICTRELIS┬« (boceprevir) 200 mg Capsules. cEVR was assessed by the proportion of patients who achieved undetectable virus (HCV RNA) at treatment week (TW) 12 in the investigational arms and at TW 16 in the control arm. The MK-5172 regimens had rates of cEVR ranging from 82.8 to 93%, versus the control of 74.2%. 

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58.55
0.38 +0.65%
9 Jul 2014