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Pfizer Inc reports positive phase 3 Study outcome Of XALKORI (crizotinib) compared to chemotherapy in previously untreated patients with ALK-positive advanced non-small cell lung cancer

Tuesday, 25 Mar 2014 08:30am EDT 

Pfizer Inc:PROFILE 1014, Phase 3 study of anaplastic lymphoma kinase (ALK) inhibitor XALKORI(crizotinib).Met its primary objective of significantly prolonging progression-free survival (PFS) in previously untreated patients with ALK-positive advanced non-squamous non-small cell lung cancer (NSCLC) when compared to standard platinum-based chemotherapy regimens.PROFILE 1014 is second positive global Phase 3 study that evaluated XALKORI against chemotherapy, a standard of care for patients with advanced NSCLC.No unexpected safety issues were identified in the PROFILE 1014 study. 

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