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Peregrine Pharmaceuticals Inc announces preclinical data shows combination of Peregrine Pharmaceuticals' PS-Targeting Antibodies and Anti-PD-1 Antibodies Significantly Reduce Breast Cancer Progression

Monday, 11 Aug 2014 08:00am EDT 

Peregrine Pharmaceuticals Inc:Says preclinical data further validating potent immune-stimulatory mechanism of its phosphatidylserine (PS)-targeting immuno-oncology platform.Results show that combination of PS-targeting antibody equivalent to bavituximab administered with an anti-PD-1 antibody displayed statistically significant tumor growth suppression.Says while also demonstrating significant increase in tumor-fighting T-cells into tumor microenvironment compared to anti-PD-1 antibody treatment alone in immune competent animal model of breast cancer.Bavituximab is currently being evaluated in second-line non-small cell lung cancer (NSCLC) as part of the SUNRISE pivotal Phase III clinical trial.Says these data further validate that blocking the immunosuppressive effects of PS facilitate an increase in tumor-fighting T-cells, and that the combination with PD-1 then allows for a more effective anti-tumor T-cell response. 

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