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Sanofi SA and Regeneron report positive results with Alirocumab from Phase 2 Japanese study


Tuesday, 1 Apr 2014 08:06am EDT 

Sanofi SA And Regeneron Pharmaceuticals Inc:Says that the first Phase 2 study with alirocumab, an investigational monoclonal antibody targeting PCSK9 (proprotein convertase subtilisin/kexin type 9), in Japanese patients met its primary endpoint.The results demonstrated that the mean low-density lipoprotein-cholesterol (LDL-C, or bad cholesterol) percentage reduction from baseline to week 12.The primary efficacy endpoint of the study, was significantly greater in patients randomized to receive one of three doses of alirocumab administered every other week (Q2W) -- 150 milligrams (mg), 75 mg, and 50 mg, in combination with statin therapy, compared to patients receiving placebo.