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Seattle Genetics Inc Announces Data from Phase I Trial of ADCETRIS (Brentuximab Vedotin) in Front-line Mature T-Cell Lymphomas (MTCL)

Sunday, 9 Dec 2012 12:00pm EST 

Seattle Genetics Inc announced results from a phase I clinical trial of ADCETRIS (brentuximab vedotin) in combination with chemotherapy for the treatment of newly diagnosed mature T-cell lymphoma (MTCL) patients, including patients with systemic anaplastic large cell lymphoma (sALCL). The data were presented at the 54th American Society of Hematology (ASH) Annual Meeting and Exposition being held December 8-11, 2012 in Atlanta, GA. ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30. ADCETRIS is not currently approved for use in the front-line treatment of MTCL. Data were reported from 26 previously untreated patients who received the combination regimen of ADCETRIS plus CHP. Nineteen patients had sALCL, and seven patients had a diagnosis of another mature T- or NK-cell lymphoma. The median age of patients was 56 years. Key findings, which were highlighted in an oral presentation by Dr. Fanale, include: All 26 patients (100%) achieved an objective response after either completing six cycles of combination therapy or at the latest assessment for three patients who discontinued treatment prior to cycle six. Twenty-three patients (88%) achieved a complete remission and three patients (12%) achieved a partial remission. Among 19 sALCL patients, 19 (100%) achieved an objective response, including 16 (84%) with a complete remission. 

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