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Starpharma Holdings Ltd's Dendrimer-Oxaliplatin Shows Better Anti-cancer Efficacy And Less Toxicity
Starpharma Holdings Ltd announced it had achieved improved tumour-inhibiting efficacy and reduced overall toxicity using a dendrimer enhanced version of the blockbuster cancer drug, oxaliplatin (ELOXATIN). These positive results were demonstrated in a pre-clinical study, which examined dendrimer-enhanced nanoparticle versions of oxaliplatin compared with ELOXATIN (oxaliplatin) in a colon cancer model (xenograft). Oxaliplatin is primarily used to treat colon and colorectal cancer. Bone marrow toxicities (including the serious white blood cell disorder, neutropenia1) are reported in a high proportion of patients receiving Oxaliplatin – with rates in excess of 70%. The observation that Starpharma’s Dendrimer-Enhanced Oxaliplatin nanoparticles substantially reduced neutropenia, a life threatening and dose-limiting toxicity is an important finding, both for this drug candidate (Dendrimer-Enhanced Oxaliplatin) and potentially also for Starpharma’s platform more broadly. These positive results achieved with Starpharma’s Dendrimer-Enhanced Oxaliplatin nanoparticles are the subject of a new patent filing and given the obvious commercial potential, Starpharma now intends to advance Dendrimer-Enhanced Oxaliplatin formulations into development. Additional studies are ongoing to further explore the positive impact on bone marrow toxicity and the potential for the Dendrimer-Enhanced nanoparticles to reduce certain other clinically important toxicities.
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