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TG Therapeutics Inc's TG-1101 in combination with Ibrutinib demonstrates compelling clinical activity and safety profile in patients

Friday, 13 Jun 2014 05:30am EDT 

TG Therapeutics Inc:Announces preliminary clinical results from its ongoing Phase 2 study of TG-1101 (ublituximab).The company's novel glycoengineered anti-CD20 monoclonal antibody, in combination with ibrutinib (IMBRUVICA), the oral BTK inhibitor from Pharmacyclics/Janssen.TG-1101 in combination with ibrutinib was well tolerated in the 28 patients evaluable for safety, with Day one infusion related reactions (IRR) being the most frequently reported adverse event for TG-1101.All but one IRR were Grade one or two in severity and were manageable without dose reductions.Says Ibrutinib related adverse events included diarrhea and rash with one patient discontinuing treatment due to ibrutinib related diarrhea (only patient to discontinue from the study to date). 

Company Quote

0.75 +4.78%
19 Dec 2014