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Shire PLC (SHP.L)

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Summary

Name Age Since Current Position

Susan Kilsby

57 2014 Non-Executive Chairman of the Board

Flemming Ornskov

58 2013 Chief Executive Officer, Executive Director

Jeffrey Poulton

48 2015 Chief Financial Officer, Executive Director

Ginger Gregory

2014 Chief Human Resource Officer

Bill Mordan

2015 General Counsel, Company Secretary

Phil Vickers

56 Head of Research and Development

Olivier Bohuon

57 2015 Non-Executive Director

Gail Fosler

68 2016 Non-Executive Director

Sara Mathew

60 2015 Non-Executive Director

Albert Stroucken

68 2016 Non-Executive Director

Dominic Blakemore

46 2014 Non-Executive Independent Director

William Burns

68 2016 Senior Non-Executive Independent Director

Steven Gillis

2012 Non-Executive Independent Director

David Ginsburg

63 2010 Non-Executive Independent Director

Anne Minto

62 2010 Non-Executive Independent Director

Biographies

Name Description

Susan Kilsby

Ms. Susan Saltzbart Kilsby is Non-Executive Chairman of the Board of Shire Plc., Effective April 29, 2014. She brings to her role extensive M&A and finance experience having enjoyed a distinguished global career in investment banking. She held senior positions with The First Boston Corporation, Bankers Trust, Barclays de Zoete Wedd and most recently Credit Suisse where she was Chairman of the EMEA Mergers & Acquisitions team until 2009 and a part-time senior advisor until 2014. Susan is also a former Director of L’Occitane International S.A. and Coca-Cola HBC AG. She holds a BA in Economics and a MBA. Key appointments: BBA Aviation plc (Non-Executive Director), Keurig Green Mountain, Inc. (Non-Executive Director) and Fortune Brands Home & Security, Inc. (Non-Executive Director).

Flemming Ornskov

Dr. Flemming Ornskov, M.D., MBA, MPH, is Chief Executive Officer, Executive Director of Shire Plc., Effective April 30, 2013. He brings to his role his operational and medical knowledge and his extensive international, strategic and operational experience in the pharmaceutical sector. He formerly held the position of Non-Executive Chairman of Evotec AG and was Non-Executive Director of PCI Biotech Holding ASA. From 2010 to 2012 he was Chief Marketing Officer and Global Head, Strategic Marketing for General and Speciality Medicine at Bayer. From 2008 to 2010 Flemming served as Global President, Pharmaceuticals and OTC at Bausch & Lomb, Inc. He also served as Chairman, and later as President and Chief Executive Officer, of Life-Cycle Pharma A/S from 2006 to 2008, and as President and Chief Executive Officer of Ikaria, Inc. from 2005 to 2006. Earlier in his pharmaceutical career Flemming held roles of increasing responsibility at Merck & Co., Inc. and Novartis AG, following a distinguished period spent in hospitals and academic medicine. Flemming received his MD from the University of Copenhagen, MBA from INSEAD and Master of Public Health from Harvard University.

Jeffrey Poulton

Mr. Jeffrey Poulton is Chief Financial Officer, Executive Director of the Company. He brings to the Board his financial, commercial and strategic acumen. Since joining Shire in 2003 he has held leadership positions in finance supporting the Neuroscience, Gastrointestinal and Rare Diseases business units as well as the positions of Interim Chief Financial Officer and Head of Investor Relations. In addition, Jeff oversaw the operations of the Rare Diseases business unit in North America, Latin America and Asia Pacific, as well as leading the integration of the legacy-Viropharma rare disease products into the Shire portfolio. Prior to joining Shire, Jeff spent time at Cinergy Corp. and PPG Industries in a variety of corporate finance and business development roles, in addition to serving as a commissioned officer in the U.S. Navy. He received a Bachelor of Arts in Economics from Duke University and a Master of Business Administration in Finance from the Kelly School of Business at Indiana University.

Ginger Gregory

Ms. Ginger Gregory is an Chief Human Resource Officer of the company. She joined Shire in 2014 and is Shire’s Chief Human Resources Officer. She is also a member of the Executive Committee. Ginger was previously Head of Human Resources at Dunkin’ Brands Group, Inc. prior to which she held various roles at Bristol-Myers Squibb Company, Novo Nordisk A/S and Novartis AG.

Bill Mordan

Mr. Bill Mordan is General Counsel, Company Secretary of the Company. He is also a member of Shire's Executive Committee. Bill was previously at Reckitt Benckiser in the UK and US. Prior to that he held various roles at Procter & Gamble in the US, Mexico and Brazil. During his career, he also served as a clerk in the U.S. Court of Appeals for the Sixth Circuit.

Phil Vickers

Mr. Phil J. Vickers is Head of Research and Development of the Company. He joined Shire in 2010 and is Shire’s Head of Research and Development. He is also a member of the Executive Committee. Phil previously led Research and Development for the Rare Disease Business Unit prior to which he held various roles at Boehringer Ingelheim Pharmaceuticals, Pfizer, and Merck & Co.

Olivier Bohuon

Mr. Olivier Bohuon is Non-Executive Director of the Company. He brings to the Board his extensive international business and leadership experience gained through roles held in pharmaceutical and healthcare companies across Europe, the Middle East and the US. He currently holds the position of Chief Executive Officer at Smith & Nephew plc, having previously served as Chief Executive Officer and President of Pierre Fabre Group and as President of Abbott Pharmaceuticals; a division of US-based Abbott Laboratories. Olivier has also held diverse commercial leadership positions at GlaxoSmithKline and its predecessor companies in France. He has an MBA from HEC Paris School of Management and a doctorate in Pharmacy from the University of Paris.

Gail Fosler

Ms. Gail D. Fosler is Non-Executive Director of the company. She is President of The GailFosler Group LLC, a strategic advisory service for global business leaders and public policy makers, which she has led since 2010. Prior to that, Ms. Fosler spent more than 20 years at The Conference Board, a global research and business membership organization, where she held several positions including President, Executive Vice President and Chief Economist. Ms. Fosler currently serves as a director of Baxalta and of Swiss Reinsurance America Corporation, and as Chairman of Deschner Corporation. Previously, Ms. Fosler served as a director of Baxter International Inc and Caterpillar Inc.

Sara Mathew

Ms. Sara Mathew is Non-Executive Director of the Company. She brings to the Board her financial, strategic and technological experience having held various corporate leadership roles. Until 2013 Sara served as Chairman, President and Chief Executive Officer of Dun & Bradstreet, Inc. having spent 12 years at the company. Prior to this, Sara worked for 18 years at Procter & Gamble where she held a variety of global finance and management positions including Vice President, Finance, Australia, Asia and India. Sara received her MBA from Xavier University, her Accounting degree from the Institute of Cost & Works Accountants and her Bachelor’s degree in Physics, Mathematics and Chemistry from the University of Madras. Key appointments: Avon Products, Inc. (Non-Executive Director), Campbell Soup Company (Non-Executive Director), Freddie Mac (Non- Executive Director) and Zurich Financial Services Group (International Advisory Council Member).

Albert Stroucken

Mr. Albert P. L. Stroucken is Non-Executive Director of the company. He is Executive Chairman of Owens-Illinois Inc, a glass packaging company, having served as Chairman, President and Chief Executive Officer from 2006 until 2015. Between 1998 and 2006 Mr. Stroucken served as President and Chief Executive Officer, and then Chairman, of H.B. Fuller Company, a manufacturer of adhesives, sealants, coatings, paints and other specialty chemicals. From 1997 to 1998 he was General Manager of the Inorganics Division of Bayer AG. From 1992 to 1997 Mr. Stroucken was Executive Vice President and President of the Industrial Chemicals Division of Bayer Corporation. Mr. Stroucken currently serves as a director of Baxter International Inc and of Baxalta.

Dominic Blakemore

Mr. Dominic Blakemore is Non-Executive Independent Director of Shire Plc. Since 1 January 2014. He brings to the Board his strategic and financial experience. He holds the position of Group Chief Operating Officer, Europe at Compass Group PLC having previously served as Chief Financial Officer. He has also held the positions of Chief Financial Officer at Iglo Foods Group and European Finance & Strategy Director, Corporate Finance Director, and Group Financial Controller at Cadbury plc. Earlier in his career Dominic worked at PricewaterhouseCoopers where he advised pharmaceutical sector clients. Key appointments: Compass Group PLC (Group Chief Operating Officer, Europe) and Academic Council of University College London (Member).

William Burns

Mr. William Burns has been re-designated as Senior Non-Executive Independent Director of Shire Plc., effective 28 April 2016. He brings to the Board extensive international R&D, commercial, business development and operational experience in the pharmaceutical sector. He worked for Roche from 1986 until 2009; most recently holding the position of CEO of their pharmaceuticals division and serving as a member of the Roche Group Corporate Executive Committee. Bill holds a BA (Hons). Key appointments: Masters Pharmaceuticals (Chairman), Biotie Therapies Corp. (Chairman), Mesoblast Limited (Non-Executive Director), Vestergaard Frandsen (Vice Chairman), Wellcome Trust (Committee Chairman), Institute of Cancer Research (Trustee) and University of Cologne/Bonn Center for Integrated Oncology (Scientific Advisory Board Member).

Steven Gillis

Dr. Steven H. Gillis, Ph.D. is Non-Executive Independent Director of Shire plc., Since October 1, 2012. He brings to the Board his extensive technical and scientific knowledge and commercial experience. He is currently a Managing Director at ARCH Venture Partners; a provider of venture capital for technology firms. Prior to this Steven was a founder and Director of Corixa Corporation, acquired by GlaxoSmithKline in 2005, and before that a founder and Director of Immunex Corporation. An immunologist by training Steven has authored more than 300 peer-reviewed publications in the areas of molecular and tumor immunology. He is credited as being a pioneer in the field of cytokines and cytokine receptors, directing the development of multiple marketed products including Leukine, (GM-CSF), Prokine (IL-2) and Enbrel (soluble TNF receptor-Fc fusion protein) as well as the regulatory approval of Bexxar (radiolabeled anti-CD20) and the novel vaccine adjuvant, MPL. Steven received his BA from Williams College and his Ph.D. from Dartmouth College.

David Ginsburg

Dr. David Ginsburg, M.D., is an Non-Executive Independent Director of the Company. He brings to the Board his clinical medical experience in internal medicine, hematology-oncology and medical genetics, as well as his extensive basic biomedical laboratory research expertise. David obtained his BA at Yale University, MD at Duke University and completed his medical and research training at Harvard Medical School. David is the recipient of numerous honors and awards, including election to membership at the National Academy of Sciences, the Institute of Medicine and the American Academy of Arts and Sciences.

Anne Minto

Ms. Anne Elizabeth Minto OBE, is Non-Executive Independent Director of Shire Plc., Since June 16, 2010. She brings to the Board her extensive legal, commercial and remuneration experience. She held the position of Group Director, Human Resources at Centrica plc from 2002 to 2011 and was a member of the Centrica Executive Committee. Her extensive business career includes senior management roles at Shell UK, the position of Deputy Director-General of the Engineering Employers’ Federation and the position of Group Director Human Resources at Smiths Group plc. She is also a former Director of Northumbrian Water plc and SITA UK. Anne holds a Law degree, a postgraduate diploma in Human Resources and is a qualified lawyer. She is also a Fellow of the Chartered Institute of Personnel & Development, the Royal Society of Arts and the London City and Guilds, and is a member of the Law Society of Scotland. Key appointments: Tate & Lyle PLC (Non- Executive Director), ExlService Holdings, Inc. (Non-Executive Director), University of Aberdeen Court (Non-Executive Director) and University of Aberdeen Development Trust (Vice Chairman and Trustee).