Profile: Affymetrix Inc (AFFX.O)
17 Dec 2013
Affymetrix, Inc. (Affymetrix), incorporated in March 1992, is engaged in the development, manufacture, sale and service of consumables and systems for genetic analysis in the life sciences and clinical healthcare markets. Affymetrix has developed its GeneChip system and related microarray technology as a platform for acquiring, analyzing and managing genetic information. The Company offers a line of products for two principal applications: genotyping and gene expression. Related microarray technology also offered by Affymetrix includes licenses for fabricating, scanning, collecting and analyzing results from complementary technologies. The Company sells its products directly to pharmaceutical, biotechnology, agrichemical, diagnostics and consumer products companies, as well as academic research centers, government research laboratories, private foundation laboratories and clinical reference laboratories in North America and Europe. The Company also sells some of its products through life science supply specialists acting as authorized distributors in Latin America, India, the Middle East and Asia Pacific regions, including China. In June 2012, the Company acquired eBioscience Holding Company, Inc., a company with in flow cytometry and immunoassay reagents for immunology and oncology research and diagnostics. In October 2013, StoneCalibre announced that the completion of the acquisition of Anatrace, a part of Affymetrix, Inc.
The Company’s integrated GeneChip microarray platform includes: disposable deoxyribonucleic acid (DNA) probe arrays (chips) consists of nucleic acid sequences and other instruments used to process the probe arrays, and software to analyze and manage genomic or genetic information obtained from the probe arrays. The Company’s technologies include array technology and branched DNA (bDNA) technology. The Company’s array technology leverages semiconductor-based photolithographic fabrication techniques, which enables it to synthesize a variety of predetermined DNA sequences simultaneously in predetermined locations on a small glass chip called an array.
Affymetrix offers customers a suite of assay products for a variety of low- to mid-plex genetic, protein and cellular analysis applications using bDNA, technology. These assays measure ribonucleic acid (RNA) levels directly from samples. The majority of the Company’s product sales consist of sales of instruments and related consumables. The Company has three families of instrument systems, GeneChip, GeneTitan and GeneAtlas, which include instruments, consumables and software. Affymetrix’s GeneChip instruments run arrays packaged in cartridges and its GeneTitan and GeneAtlas instruments run arrays packaged in a peg format for automated throughput processing. It also offers a variety of assays for gene expression targeting low- to mid-plex markets. It offers high-throughput genotyping services for customers using its genotyping products. The Company’s projects range in size from a few hundred samples to over 10,000 samples.
GeneChip Family of Products
The Company’s GeneChip system provides an integrated solution for gene expression and genotyping analysis. It consists of instruments and consumables that provide for the preparation and analysis of samples using its GeneChip cartridge arrays. The components of the GeneChip system include disposable probe arrays containing genetic information on a chip; reagents for extracting, amplifying and labeling target nucleic acids; a fluidics station for introducing the test sample to the probe arrays; a hybridization oven for optimizing the binding of samples to the probe arrays; a scanner to read the fluorescent image from the probe arrays, and software to analyze and manage the resulting genetic information. The Company’s major GeneChip instrument products include GeneChip Scanner 3000, GeneChip Scanner 3000Dx, GeneChip Fluidics Station and GeneChip Hybridization Oven. Its major GeneChip array and reagent products include Genotyping Catalog Cartridge Array, which includes CytoScan HD Array, SNP 6.0 Array, DMET Plus; Gene Expression Catalog Cartridge Arrays, which consists of U133, other arrays, and Custom Arrays, which includes MyGeneChip and CustomSeq.
GeneTitan Family of Products
Affymetrix’s GeneTitan family of products consists of the GeneTitan instrument system that runs genotyping and gene expression array plates. The GeneTitan family of products provides a solution for monitoring gene expression and genome-wide single-nucleotide polymorphisms (SNP) genotyping. Its GeneTitan products include, GeneTitan, Axiom Genotyping Solution and Gene Expression Array Plates. The Company’s GeneAtlas products include: GeneAtlas Personal Microarray System and Gene Expression Array Plates.
Low- to Mid-plex Products
The Company also offers a line of multiplex assays to serve both the discovery and the validation markets. Multiplex assays measure many different targets from the same sample. These products enable drug target identification through analysis of gene silencing, cell signaling and biomarker validation. Its QuantiGene line of products is based on bDNA technology and delivers quantitative gene expression analysis.
Affymetrix offers researchers a line of reagent kits, enzymes and biochemicals. The Company’s reagents are complementary to its array portfolio, thus enabling it to provide its customers with product solutions. In addition, they can be applied to a variety of emerging technologies. The Company’s reagents include ExoSAP-IT For PCR Product Clean-Up, a reagent for the clean-up of polymerase chain reaction (PCR) products used in downstream applications, such as DNA sequencing or SNP analysis, and HotStart-IT line of PCR reagents, reagents that utilize a binding protein to inhibit dimer formation.
The Company competes with Illumina, Inc., Life Technologies Corporation, Pacific Biosciences of California, Inc, Agilent Technologies, Inc., BD Biosciences, CombiMatrix Corporation, MDS Analytic Technologies/Danaher, Nimblegen/Roche Diagnostics, NuGEN Technologies, Inc, BioRad Laboratories, Inc, Fluidigm Corporation, Sequenom, Inc., High Throughput Genomics, Inc., Beckman Coulter, Inc., NanoString Technologies, Becton, Dickinson and Company, bioMerieux, Johnson & Johnson, Gen-Probe Incorporated, Complete Genomics, Inc. and Celera Diagnostics.
3420 Central Expressway
SANTA CLARA CA 95051