Profile: Eli Lilly and Co (LLY.N)
28 Nov 2014
Eli Lilly and Company, incorporated on September 17, 1901, discovers, develops, manufactures, and sells products, in one business segment, pharmaceutical products. The Company also has an animal health business segment. It manufactures and distributes its products through facilities in the United States, Puerto Rico, and 15 other countries. Its products are sold in approximately 130 countries. The Company’s products include neuroscience products, endocrinology products, oncology products, cardiovascular products, animal health products and other pharmaceuticals. The Company’s new molecular entities (NMEs) are in Phase III clinical trial testing include Dulaglutide, Edivoxetine, Empagliflozin-BI10773, Enzastaurin, Ixekizumab, Necitumumab,, New insulin glargine product, Novel basal insulin analog, Pomaglumetad Methionil, Ramucirumab, Solanezumab and Tabalumab. In the United States, it distributes pharmaceutical products principally through independent wholesale distributors, with some sales directly to pharmacies. In February 2012, the Company acquired ChemGen Corp. On July 7, 2011, it acquired the animal health business of Janssen, a Johnson & Johnson company. In January 2014, acquired all development rights for a calcitonin gene-related peptide (CGRP) antibody. In July 2014, Anthera Pharmaceuticals Inc acquired Sollpura (liprotamase), a investigational Pancreatic Enzyme Replacement Therapy (PERT) from Eli Lilly and Company.
The Company’s neuroscience products include Zyprexa, Zyprexa Relprevv (Zypadhera in the European Union), Cymbalta, Strattera, Prozac and Symbyax. Zyprexa is used for the treatment of schizophrenia, acute-mixed or manic episodes associated with bipolar I disorder and bipolar maintenance. Zyprexa Relprevv (Zypadhera in the European Union) is a long-acting intramuscular injection formulation of Zyprexa. Cymbalta is used for the treatment of depressive disorder, diabetic peripheral neuropathic pain and generalized anxiety disorder. In addition, Cymbalta, in the United States, is used for the management of fibromyalgia and of chronic musculoskeletal pain due to chronic low back pain or chronic pain due to osteoarthritis. Strattera is used for the treatment of attention-deficit hyperactivity disorder in children, adolescents, and in the United States in adults. Prozac is used for the treatment of depressive disorder, obsessive-compulsive disorder, bulimia nervosa and panic disorder. Symbyax is used for the treatment of bipolar depression and treatment-resistant depression.
Endocrinology products include Humalog, Humalog Mix 75/25, Humalog Mix 50/50, Humulin, Byetta, Bydureon , Actos, Evista, Forteo, Humatrope and Axiron. Humalog, Humalog Mix 75/25, Humalog Mix 50/50, Humulin are used for the treatment of diabetes. Byetta and Actos are used for the treatment of type 2 diabetes. Bydureon, approved in Europe in 2011 and in the United States in January 2012, for the treatment of type 2 diabetes. Evista is used for the prevention and treatment of osteoporosis in postmenopausal women and for the reduction of the invasive breast cancer in postmenopausal women with osteoporosis and postmenopausal women at high risk for invasive breast cancer. Forteo is used for the treatment of osteoporosis in postmenopausal women and men at high risk for fracture and for glucocorticoid-induced osteoporosis in postmenopausal women and men. Humatrope is used for the treatment of human growth hormone deficiency and n pediatric growth conditions. Axiron is a solution of testosterone, applied by underam applicator, for replacement therapy in men for conditions associated with a deficiency or absence of testosterone.
The Company’s oncology products include Alimta, Gemzar and Erbitux. Alimta is used for the treatment, in combination with another agent, of non-small cell lung cancer for patients with non-squamous histology. It is also used for the treatment of non-small cell lung cancer, and in combination with another agent, for the treatment of malignant pleural mesothelioma. Gemzar is used for the treatment of pancreatic cancer, in combination with other agents, for the treatment of metastatic breast cancer, non-small cell lung cancer, and advanced or recurrent ovarian cancer. Gemzar is also used in the European Union for the treatment of bladder cancer. Erbitux is indicated both as a single agent and with another chemotherapy agent used for the treatment of types of colorectal cancers. Erbitux, as a single agent or in combination with radiation therapy, is used for the treatment of types of head and neck cancers.
Cardiovascular products include Cialis, Effient, ReoPro, Adcirca and Livalo. Effient is used for the reduction of thrombotic cardiovascular events, including stent thrombosis, in patients with acute coronary syndrome who have managed with an artery-opening procedure, percutaneous coronary intervention (PCI). Effient is used by patients who are undergoing angioplasty, atherectomy or stent placement. ReoPro is used as an adjunct to PCI for the prevention of cardiac ischemic complications. Adcirca is used for the treatment of pulmonary arterial hypertension. Livalo is a statin medication for use as an adjunct to diet in the treatment of high cholesterol (primary hyperlipidemia or mixed dyslipidemia).
Animal health products
Animal health products include Rumensin, Tylan, Micotil, Paylean and Optaflexx, Coban, Monteban, Maxiban, Apralan, Surmax, Comfortis, Trifexis and Reconcile. Rumensin is a cattle feed additive that controls and prevents coccidiosis. Tylan is an antibiotic used to control diseases in cattle, swine, and poultry. Micotil, Pulmotil and Pulmotil AC antibiotics are used to treat respiratory disease in cattle, swine and poultry. Paylean and Optaflexx are performance enhancers for swine and cattle, respectively. Posilac is a protein supplement to improve milk productivity in dairy cows. Coban, Monteban and Maxiban are anticoccidial agents for use in poultry. Apralan is an antibiotic used to control enteric infections in calves and swine. Surmax (sold as Maxus in some countries), is a performance enhancer for swine and poultry. Elector is a parasiticide for use on cattle and premises. Comfortis is a chewable tablet that kills fleas and prevents flea infestations on dogs. Trifexis is a monthly chewable tablet for dogs that kills fleas, prevents flea infestations, prevents heartworm disease, and controls intestinal parasite infections
Reconcile is used for treatment of canine separation anxiety in conjunction with behavior modification training.
The Company’s other pharmaceuticals include Vancocin HCl and Ceclor. Vancocin HCl is used primarily to treat staphylococcal infections. Ceclor is used for the treatment of a range of bacterial infections.
Eli Lilly and Co
Lilly Corporate Center
INDIANAPOLIS IN 46285