Profile: NuVasive Inc (NUVA.OQ)
26 May 2017
Nuvasive, Inc., incorporated on July 21, 1997, is a medical device company. The Company focuses on developing minimally-disruptive surgical products and procedurally-integrated solutions for the spine surgery. The Company's product portfolio focuses on applications for spine fusion surgery, including biologics used to aid in the spinal fusion process. The Company's principal product offering includes a minimally-disruptive surgical platform called Maximum Access Surgery (MAS). The platform includes the Company's software-driven nerve detection and avoidance systems, including NVM5, and intraoperative monitoring (IOM) services and support; MaXcess, which is an integrated split-blade retractor system, and a range of implants and biologics. The MAS platform combines three product categories: its MaXcess retractors, specialized implants and fixation products, and nerve monitoring systems and service offerings that collectively enable surgeons to detect and navigate around nerves, while directing customized access to the spine for implant delivery.
The Company's products, including the individual components of its MAS platform are used in open or traditional spine surgery. The Company's MAS platform allows surgeons to perform a range of minimally-disruptive spine procedures in all regions of the spine. The platform is designed to treat various spinal pathologies. Its products facilitate minimally-disruptive applications of various surgery procedures, including lumbar and thoracic fusion procedures in which the surgeon approaches the spine through the patient's back, side or abdomen; cervical fusion procedures for either the posterior occipito-cervico-thoracic region or the anterior cervical region, and decompression, which is the removal of a portion of bone or disc from over or under the nerve root to relieve pinching of the nerve. The Company also offers products to treat the unmet clinical needs of children suffering from early onset scoliosis (EOS) and patients suffering from limb length discrepancies. The Company's MAGEC-EOS Spinal Bracing and Distraction System allows for the minimally invasive treatment of early-onset and adolescent scoliosis. The Company's PRECICE Limb Lengthening System allows for the correction of long bone limb length discrepancy, as well as bone healing in patients that have experienced traumatic injury.
MaXcess retractors have a split-blade design, which provides customizable access to the spine allowing surgeons to perform surgical procedures using instruments that are similar to those used in open procedures. Its system's illumination of the operative corridor aids in providing surgeons with direct visualization of the patient's anatomy. Its MaXcess products are used in the cervical spine for posterior application and anterior retraction, the lumbar spine for decompressions, transforaminal lumbar interbody fusions (TLIFs) and posterior lumbar interbody fusions (PLIFs), the thoracolumbar spine for eXtreme Lateral Interbody Fusion (XLIFs), and the thoracic region for tumors and trauma, as well as in adult degenerative scoliosis procedures.
Implants and Fixation Systems
The Company has implants and fixation devices designed to be used with its MAS platform. These implants are used for interbody disc height restoration. Its implants are made from allograft, titanium and polyetheretherketone (PEEK). Its CoRoent family of implants, which are made from PEEK, are available in a range of shapes and sizes to accommodate specific approach, pathology and anatomical requirements of the patient and the particular fusion procedure. Its implants are designed for insertion into the smallest possible space, while maximizing surface area contact for fusion. Its fixation products, including pedicle screws, rods and plates, have been designed and include a differentiated percutaneous minimally invasive solution with guide technology, superior rod insertion options and multiple reduction capabilities to be delivered through its procedures to provide stabilization of the spine. Its fixation offerings include its Armada, Precept and Reline posterior fixation portfolios.
The Company's nerve monitoring systems utilize electromyography (EMG), as well as software hunting algorithms and graphical user interfaces to provide surgeons with a nerve avoidance system. The Company's systems function by monitoring changes in electrical signals across muscle groups, which allows the Company to detect underlying changes in nerve activity. Through the NVM5 platform, the Company gives surgeons the option to connect their instruments to a computer system that provides discrete, real-time, surgeon directed and surgeon controlled feedback about the directionality and relative proximity of nerves during surgery. The Company's systems analyze and then translate neurophysiologic data. The health and integrity of the spinal cord and related nerves can also be assessed using motor evoked potentials (MEPs) and somatosensory evoked potentials (SSEPs). Both of these methods of IOM involve applying stimulation and recording the response that must travel along the motor or sensory paths of the spinal cord. In addition to its MAS platform, the Company's procedural solution includes its biologics products, IOM services and iGA technology.
The Company's allograft biologics product offerings include Osteocel Plus and Pro, a cellular bone matrix designed to mimic the biologic profile of autograft, including mesenchymal stem cells and osteoprogenitor cells to aid in spinal fusion. Its synthetic biologics product offerings include Formagraft (collagen-based synthetic bone substitute), AttraX (synthetic bone graft material delivered in putty form), and Propel Demineralized Bone Matrix (DBM) putty (moldable DBM putty).
Intraoperative Monitoring Services
Through its IOM services business, the Company provides onsite and remote monitoring of the neurological systems of patients undergoing spinal and brain-related surgeries. Its neurophysiologists are present in the operating room during procedures and work in partnership with physicians who remotely oversee and interpret neurophysiological data gathered through broadband transmission over the Internet. Through this service, data can be analyzed in real time by healthcare professionals for additional interpretation of intraoperative information and oversight.
Integrated Global Alignment
The Company's iGA platform offers a global approach for assessing, preserving and restoring spinal alignment. Using its NuvaPlanning portfolio of software solutions, including NuvaMap, NuvaLine and NuvaMap O.R., surgeons can preoperatively calculate and evaluate alignment parameters and implant integration by modeling surgery to create a reliable plan with results, and then conduct a real-time interoperative assessment in order to correct the anterior and posterior column alignment in line with the surgical plan. In addition to its software solutions, the Company also offers products that are designed to restore alignment, including its ReLine posterior fixation portfolio and its Bendini spinal rod bending system.
The Company competes with Medtronic Sofamor Danek USA, Inc., Johnson & Johnson, Stryker Spine, Globus Medical, Zimmer Biomet Spine, Orthofix International N.V., Alphatec Spine, K2M, SpecialtyCare and Becton, Dickinson and Company.
7475 Lusk Blvd
SAN DIEGO CA 92121-5707
Company Web Links
- BRIEF-NuVasive announces FDA 510(K) clearance of Coroent small interbody system
- Bets on financials, pharma power U.S. hedge funds' strong start to year
- Bets on financials, pharma power U.S. hedge funds' strong start to year
- BRIEF-Nuvasive sees FY 2017 revenue $1.065 bln
- BRIEF-Nuvasive repurchased about $49.6 mln in aggregate principal amount of its 2.75 PCT convertible senior notes due 2017