Profile: PerkinElmer Inc (PKI.N)
29 Aug 2014
PerkinElmer, Inc., November 13, 1947, is a provider of products, services and solutions to the diagnostics, research, environmental, industrial and laboratory services markets. Through the Company’s advanced technologies, solutions, and services, it addresses issues related to health and safety of people and their environment. It operates in two segments: Human Health and Environmental Health.
Human Health Segment
The Company’s Human Health segment concentrates on developing diagnostics, tools and applications to help detect diseases earlier and accelerate the discovery and development of critical new therapies. Within the Human Health segment, it serves both the diagnostics and research markets. It provides detection for genetic disorders from pre-conception to early childhood, as well as digital x-ray flat panel detectors and infectious disease testing for the diagnostics market. Its screening products are designed to provide insights into the health of expectant mothers during pregnancy and into the health of their newborns. Its instruments, reagents and software test and screen for disorders and diseases, including down syndrome, infertility, anemia and diabetes. Its digital x-ray flat panel detectors are used by physicians to make fast and accurate diagnoses of conditions ranging from broken bones to reduced blood flow in vascular systems. In addition, its digital x-ray flat panel detectors improve oncology treatments by focusing radiation directly at tumors.
In the research market, the Company provides a range of solutions, including reagents, liquid handling and detection technologies, which enable researchers to improve the drug discovery process. These applications, solutions and services enable pharmaceutical companies to create therapeutics. Its research portfolio includes a range of systems consisting of instrumentation for automation and detection solutions, in vitro and in vivo imaging and analysis hardware and software, and a portfolio of consumable products, including drug discovery and research reagents. It sells its research solutions to pharmaceutical, biotechnology and academic research customers globally.
The Company’s DELFIA Xpress screening platform is a solution for prenatal screening, including a loading system supported by kits for both first and second trimester analyses, and clinically validated LifeCycle software. The NeoGram MS/MS AAAC in vitro diagnostic kit is used to support detection of metabolic disorders in newborns by tandem mass spectrometry. The Ultra-Screen screening protocol is used to provide a first trimester prenatal screening service by combining ultrasound measurement of the fluid accumulation behind the neck of the fetus with maternal serum markers. It is designed to assess patient-specific risk for Down syndrome, trisomy 18 and other chromosomal abnormalities. The GSP Neonatal hTSH, 17-OHP, GALT and IRT kits are used for screening congenital neonatal conditions from a drop of blood. The NeoBase Non-derivatized MS/MS kit analyzes newborn blood samples for measurement of amino acids and analytes for specific diseases. BACs-on-Beads (BoBs) technology detects chromosomal abnormalities. The amorphous silicon digital x-ray flat panel detectors contain an enabling technology for digital x-ray imaging, which replaces film and produces image resolution and diagnostic capability in applications, such as radiography, cardiology, angiography and cancer treatments. The DELFIA Xpress PlGF assay is designed to help clinicians screen pregnant women for early-onset pre-eclampsia during their first trimester of pregnancy. The prenatal BoBs in vitro diagnostic (IVD) assay is for rapid prenatal testing of multiple genetic diseases, for use in the European Union. The XRD 0822 and XRD 1622 digital x-ray flat panel detectors provide non-destructive testing applications, including pipeline inspection, film replacement, manufacturing inspection, three dimension (3D) Cone Beam computed tomography (CT) and printed circuit board (PCB) inspection.
The Company’s radiometric detection solutions, including over 1,100 NEN radiochemicals, the Tri-carb and MicroBeta families of liquid scintillation counters, which are used for beta, gamma and luminescence counting in microplate formats, are utilized in research, environmental and drug discovery applications. The Columbus image data storage and analysis system provides a single solution to the storage and analysis of content data from any HCS system. With the Columbus system, everyone in the lab can access, visualize and analyze content images from anywhere through the Internet. The Opera high content screening system and Operetta high content imaging system enables automated imaging and analysis for cell-based assays, providing results for decision making to drug discovery and basic cellular science research laboratories. The UltraVIEW VoX 3D live cell imaging system is a confocal imaging system, which allows for the observation and measurement of cellular and molecular processes in real time.
The Company’s EnVision multi-label reader can be used in a range of screening applications, including those utilizing AlphaLISA and/or AlphaScreen technology, and features two detectors (enabling simultaneous dual wavelength reading), below emission reading, barcode readers, a laser and flash lamp light sources, and adjustment of measurement height function. The JANUS Automated Workstation, an automation and liquid handling system, is designed for the automation of sample preparation procedures utilized in pharmaceutical, biotech, and research applications. The cell::explorer and plate::handler automated workstations allow integration of multiple laboratory instrumentation using a centralized robotic interface, allowing throughput and turnkey-application focused solutions. A range of homogeneous biochemical and cellular assay reagents, including LANCE Ultra and Alpha Technology assay platforms, are used for the drug discovery targets, such as G-protein coupled receptors (GPCR), kinases, antibodies and epigenetic modification enzymes. A portfolio of recombinant GPCR and Ion Channel cell lines includes over 300 products and 120 ready-to-use frozen cell lines for a range of disease areas. The Fluorescent Pre-clinical Imaging Agent portfolio and Fluorescence Molecular Tomography (FMT) Quantitative Pre-clinical Imaging Systems, acquired through the purchase of VisEn Medical, provide imaging data, which can be useful for identifying and characterizing a range of disease biomarkers and therapeutic efficacy in living animal models.
The Company’s Signature Precision Panel prenatal diagnostic test is used for the detection of 15 chromosomal disorders to determine genetic abnormalities during pregnancy. Oncology testing services utilize OncoChip microarray technology for diagnoses of hematological malignancies. The newborn testing and diagnostics portfolio was expanded to include a panel to screen for six Lysosomal Storage Disorders (LSDs). The panel tests for Krabbe disease, Gaucher's disease, Niemann-Pick disease (Type A and Type B), Pompe disease, Fabry disease and mucopolysaccharidosis (MPS 1). EnSpire Multimode Plate Reader with label free detection technology for drug discovery research is the benchtop detection platform to combine Corning Epic optical label free technology and traditional labeled read technologies for the identification of new therapeutic targets. The MultiSpecies Imaging Module for the Fluorescence Molecular Tomography Quantitative Pre-clinical Imaging Systems enables researchers to generate 3D in vivo animal models relevant to disease research.
The AlphaLISA research assays are for both biotherapeutics and small molecule development in a range of therapeutic areas, including cancer, neurodegeneration, and virology. The Operetta High Content Imaging System with PhenoLOGIC, machine-learning technology for intuitive cell classification enable live cell imaging assays for drug discovery and life sciences research workflow. The epigenetic detection reagents portfolio for drug discovery and life sciences research covers nine different histone marks, as well as p53, with more than 15 validated in vitro and cell-based assays to help researchers discover drug compounds directed against several epigenetic targets. Volocity 6.0 3D image analysis software allows scientists to understand intracellular and intercellular relationships. The HCA ImagAmp reagent kit for content screening and cellular analysis applications is used in a range of research areas, including cell differentiation, cell toxicity, programmed cell death, drug discovery, protein expression and signaling pathway analysis. The Vectra 2 automated slide imaging system is an integrated solution for the assessment of drug response. The FMT 1000 Quantitative Pre-clinical Imaging System is designed for the individual laboratory and measures a range of biomarkers, disease pathways and therapeutic responses in small animals in vivo.
The Company’s HypoxiSense Fluorescent Pre-clinical Imaging Agent is used to detect hypoxia to assess the therapeutic efficacy in drug screening of tumor models and fluorescence microscopy of disease tissues. AlphaScreen SureFire Assays provide a cell-based environment for assaying modulation of receptor activation, as well as measure responses of intracellular kinase inhibitors for drug discovery. Western Lighting ECL Pro, a non radioactive light-emitting system, detects proteins immobilized on a membrane in Western blots. The IVIS Spectrum CT, a preclinical imaging system, which integrates, into a single instrument system, advanced optical imaging and low dose micro computed tomography. The instrument provides insights into complex biological systems in small animals to develop new, clinically translatable discoveries. The Company’s Human Health segment offers additional products under various brand names, including AlphaLISA, AlphaScreen, AutoDELFIA, Columbus, EnSpire, EnVision, Evolution, FMT, Genoglyphix, Geospizer, inForm, IVIS, JANUS, LabChip, LANCE, LifeCycle, Living Image, Maestro, MultiPROBE, NEN, NTD Labs, Nuance, Oncoglyphix, Opera, Operetta, Packard, Pannoramic, Quantum, ScanArray, Sciclone, SignatureChip, Signature Precision Panel, Specimen Gate, SureFire, TRIO, Twister, VariSpec, Vectra, ViaCord, VICTOR, Volocity, Wizard, XRD amorphous silicon FPDs and Zephyr.
Environmental Health Segment
The Company’s Environmental Health segment provides technologies and applications to facilitate the creation of safer food and consumer products, secure surroundings and energy resources. The Environmental Health segment serves the environmental, industrial and laboratory services markets. Its water quality solutions detect substances, such as trace metal, organic, pesticide, chemical and radioactive contaminants. It provides a range of solutions, which detects the presence of materials, including lead and phthalates, in toys and other consumer products. Its solutions are also used to identify and prevent counterfeiting of medicine and other goods. It provides analytical instrumentation for the industrial market, which includes the semiconductor, chemical, petrochemical, lubricant, construction, office equipment and quality assurance industries. Its OneSource service business is aligned with customers’ needs to consolidate laboratory services. The Clarus series of gas chromatographs, gas chromatographs/mass spectrometers and the TurboMatrix family of sample-handling equipment are used to identify and quantify compounds in the environmental, forensics, food and beverage, hydrocarbon processing/biofuels, materials testing, pharmaceutical and semiconductor industries. The atomic spectroscopy family of instruments, including the AAnalyst/PinAAcle series of atomic absorption spectrometers, the Optima family of inductively coupled plasma (ICP) optical emission spectrometers and the NexION family of ICP mass spectrometers, are used in the environmental and chemical industries to determine the elemental content of a sample.
The Company’s DMA 8000, a thermal analysis system, is used by scientists in the polymers, composites, pharmaceutical, and food and beverage industries for applications ranging from quality control to research. The Spectrum Fourier transform infrared and Fourier transform near-infrared spectrometers provide a range of capabilities for infrared analysis in pharmaceuticals, fine chemicals, polymers, plastics and other industries. The Flexar liquid chromatography platform, which is controlled by the Chromera chromatography data system, incorporates an ergonomic industrial design to deliver a range of pressure and detector options for liquid chromatography laboratories. These systems are used to identify and quantify compounds for applications in the environmental, food, beverage, and pharmaceutical industries. The DSC 8000 and 8500 feature a second generation, power controlled double furnace designed to provide heating and cooling rates. The Flexar SQ 300 MS Single-Quad LC/MS detection system enables ionization of compounds in both positive and negative modes for the analysis of a range of analytes. The NexION 300 ICP mass spectrometers, with Universal Cell Technology, allow analysts to choose technique for a sample or application. The Atomax line of 1.5 inch hollow cathode lamps are designed as lighting sources, which can be used with any 1.5 inch format commercial atomic absorption spectrometer. The Velocity series capillary gas chromatography (GC) columns are fused silica columns designed for laboratory applications on the Clarus GC and any other commercial GC instrument. The columns are used in the environmental, petrochemical, food and pharmaceutical industries.
The Company’s PinAAcle Series of Atomic Absorption Spectrometers are used for the determination of metals in food, environmental samples, such as drinking water, and for use in clinical and petrochemical applications. The Optima 8x00 ICP-OES Spectrometer is a inductively coupled plasma - optical emission spectrometer. The series is designed for environmental, geochemical, pharmaceutical and food/product safety applications. The configuration of the Frontier Infrared Spectrometer is designed to provide sensitivity and performance for drug development and for determining chemical and material properties in a range of samples, including consumer products. The Spectrum Two Spectrometer is a compact and portable instrument for infrared analysis for unknown substance identification, material qualification or concentration determination in fuel and lubricant analysis, polymer analysis and pharmaceutical and environmental applications.
The Company’s Universal Operational Qualification is a service offering, which streamlines documentation across all models of laboratory instruments to help ensure compliance with regulatory standards and international guidelines. The Clarus SQ 8 GC/MS provides the mass range available in gas chromatography. The AxION 2 TOF MS platform is used for the identification of unexpected compounds in samples, providing a resolution and mass accuracy. The Supra-Clean and Supra-Poly Solid Phase Extraction column product lines offers customers a sample preparation solution. NexION 300 ICP-MS security software for pharmaceutical laboratories enables customers to comply with regulations of the United States Food and Drug Administration (FDA). The Porcine Detection Kits for the Halal food certification industry detect porcine meat traces in order to provide authenticity of food products where Halal certification is required. Its Environmental Health segment offers additional products under various brand names, including Chromera, HyperDSC, LAMBDA, LABWORKS, OneSource and Spectrum.
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