Profile: Thermo Fisher Scientific Inc (TMO)
18 Dec 2014
Thermo Fisher Scientific Inc. (Thermo Fisher), incorporated on November 10, 1960, is engaged in serving science. The Company operates in three segments: Analytical Technologies, Specialty Diagnostics and Laboratory Products and Services. The Company serves its customers through three brands: Thermo Scientific, Fisher Scientific and Unity Lab Services. Thermo Scientific is its technology brand, offering customers a range of high-end analytical instruments, as well as laboratory equipment, software, services, consumables and reagents to enable laboratory workflow solutions. Its portfolio of products includes technologies for mass spectrometry, elemental analysis, molecular spectroscopy, sample preparation, informatics, purity chemistry production, protein analysis, Ribonucleic acid (RNA)-interference techniques, immunodiagnos. Fisher Scientific is its channels brand, offering customers a portfolio of laboratory equipment, chemicals, supplies and services used in scientific research, healthcare, safety and education markets. These products are offered through an extensive network of direct sales professionals, industry-specific catalogs, e-commerce capabilities and supply-chain management services. The Company also offers a range of biopharma services for clinical trials management and biospecimen storage. Unity Lab Services is its launched services brand, offering a portfolio of enterprise services for instruments and laboratory equipment. Unity Lab Services offers a network of service and support personnel with expertise to provide its customers with solutions. In May 2011, the Company acquired Dionex Corporation. In March 2014, General Electric Co announced that its GE Healthcare, a unit of General Electric Company has acquired cell culture (sera and media), gene modulation and magnetic beads businesses from Thermo Fisher Scientific Inc.
Analytical Technologies Segment
The Company through its Analytical Technologies Segment, it provides an offering of instruments, reagents, consumables, software and services that are used for a range of applications in the laboratory, on the production line and in the field. These products are used by customers in four of its key end markets: healthcare and diagnostics; pharmaceutical and biotechnology; academic and government, and industrial and applied. This segment includes four primary businesses: Chromatography and Mass Spectrometry, Chemical Analysis, Environmental and Process Instruments, and Biosciences. Its chromatography and mass spectrometry business provides analytical instrumentation for organic and inorganic sample analysis. These products are complemented by laboratory information management systems (LIMS); chromatography data systems (CDS); database analytical tools; automation systems, and a range of consumables, such as a line of chromatography columns.
Mass spectrometry (MS) is a technique for analyzing chemical compounds, individually or in complex mixtures, by forming charged ions that are then analyzed according to their mass-to-charge ratios. In addition to molecular information, each discrete chemical compound generates a pattern that provides structurally identifiable information. Its offering includes life sciences mass spectrometry systems; inorganic mass spectrometry systems, and elemental analysis instrumentation, as well as a range of sample preparation and separation products including auto-samplers and multiplexing systems.
Life Sciences Mass Spectrometers include three product lines: triple quadrupole, ion trap and hybrid systems. Its triple quadrupole systems provide quantitative analysis of chemicals in biological fluids, environmental samples and food matrices. It is also used by the pharmaceutical industry for targeted quantitation during drug discovery. Its ion trap systems are used for in-depth structural analysis of biomolecules, such as proteins, as well as structural characterization of small molecules, such as drugs and drug metabolites. Its hybrid (LC/MS/MS) mass spectrometers combine linear ion trap, Fourier Transform Ion Cyclotron Resonance (FTICR) and Orbitrap technologies to provide high resolution and accurate mass capabilities in a single system for complex biological analyses, such as proteomics. Inorganic Mass Spectrometers include four product lines: isotope ratio mass spectrometry (IRMS); multi-collector mass spectrometry (MC/IRMS); inductively coupled plasma mass spectrometry (ICP/MS); and high resolution trace mass spectrometry (HR Trace/MS). These products are primarily used for qualitative and quantitative analysis of inorganic matter in a range of applications, including environmental analysis, materials science and earth sciences.
The Company’s chromatography product line includes high performance liquid chromatography, ion chromatography and gas chromatography systems. Liquid Chromatography (LC) Systems analyze sample matrices in liquids. Its high pressure liquid chromatography (HPLC) and ultrahigh pressure liquid chromatography (UHPLC) systems offer high throughput and sensitivity and are sold either as stand-alone systems or integrated with its mass spectrometers (LC/MS and LC/MS/MS). These systems are used for a range of applications, from proteomic analyses to routine industrial QA/QC. Ion Chromatography (IC) Systems separate ionic (charged) or polar molecules (sugars and carbohydrates), usually found in water-based solutions, and typically detect them based on their electrical conductivity. Its IC products are used in a range of applications, including scientific research, and environmental testing, as well as quality control in pharmaceutical, food and beverage, and other industrial processes. Gas Chromatography (GC) Systems analyze complex sample matrices in gases, comprising both separation and detection technology. Separation technology is common to all gas chromatography analyzers, and is paired with either a conventional detector (GC) or with different types of mass spectrometers (GC/MS). Its GC/MS offering includes a triple stage quadrupole, a single stage quadrupole, and an ion trap, for a range of applications, including food safety testing, quantitative screening of environmental samples, and complex molecular analyses.
The Company’s elemental analysis spectrometers include two product lines: atomic absorption (AA) and inductively coupled plasma (ICP) systems, which use atomic spectroscopy techniques to identify trace concentrations of elements in liquid and solid samples primarily in environmental, petrochemical, food safety, metallurgical, geochemical and clinical/toxicology research applications. These products are used in markets, such as China, India and Latin America. Enterprise-wide solutions are customizable, and include physical inventory tracking, maintenance and asset management reporting, coupled with direct and multi-vendor service capabilities.
The Company’s chemical analysis products have two categories: elemental analysis and molecular spectroscopy. Customers use these products to analyze the composition of materials in small samples to optimize workflows in academic, life sciences, pharmaceutical, and industrial applications. Its product lines range from those used in the laboratory for research or forensics, to those used on the production line. Its chemical analysis products fall into four categories: materials and minerals, molecular spectroscopy, portable analytical instruments, and materials characterization.
Materials and Minerals Products include production line, and systems for a range of industrial applications. Its laboratory elemental analyzers use X-ray fluorescence (XRF), X-ray diffraction (XRD), and arc spark optical emission (OES) techniques for analysis of bulk materials in the metals, cement, minerals, and petrochemicals industries. It also offers on line analyzers that employ neutron activation and measurement of gamma rays to analyze bulk materials non-invasively and in real time, as well as systems that enable high-speed weighing during bulk materials handling. The Company also offers gauging systems that employ ionizing and non-ionizing technologies to measure the total thickness, basis weight and coating thickness of Web-produced materials, such as plastics, foil and glass. Molecular Spectroscopy Products are divided into four primary techniques: Fourier transform infrared (FTIR), Raman, near-infrared (NIR) and ultraviolet/visible (UV/Vis) spectroscopy. These technologies are typically used in the laboratory to provide information on the structure of molecules to identify, verify and quantify organic materials in pharmaceutical, biotechnology, polymer, chemical, and forensic sciences. It also provides a range of surface analysis products commonly used in the semiconductor, metals, coatings, and polymer industries as a product development and failure analysis tool.
Portable Analytical Instruments are rugged handheld products that provide rapid, precise, real-time analysis at the point of need. Its two main product categories are elemental and optical analyzers. Its portable elemental analyzers use XRF technology for identifying metal alloys in scrap metal recycling; QA/QC; precious metals analysis; environmental analysis, and lead screening in a range of consumer products. Its portable optical analyzers utilize Raman, FTIR and NIR technologies for use in the field by first responders, and law enforcement and military personnel who need to identify chemicals and explosives in critical safety and security situations. Other applications include QA/QC in pharmaceutical production and identification of counterfeit drugs.
Materials Characterization Products include rheometers, viscometers, extruders and compounders that measure viscosity, elasticity, processability and temperature-related mechanical changes of various materials. These instruments are used in laboratory and process applications in the plastics, food, cosmetics, pharmaceutical, coatings, and petrochemical industries.
The Company’s environmental analysis instruments include portable and fixed instrumentation. Radiation Measurement and Security Instruments are used to monitor, detect and identify specific forms of radiation and trace explosives in nuclear power, environmental, industrial, medical, and security applications. Its primary customers include national, regional, and local government agencies responsible for monitoring cargo, vehicles and people traveling across borders. These products are also used by responders in safety and security situations, and for worker safety in the nuclear power and other industrial markets. Air Quality Instruments are used by environmental regulatory agencies and power plant operators to measure ambient air, stack gas emissions, and particulates to comply with regulated emissions standards. The Company provides instruments or customized Continuous Emission Monitoring Systems that monitor, collect and report data from multiple locations. its gas detection instruments detect criteria pollutants, such as nitrogen oxide, at the parts-per-trillion level. In addition, it offers particulate and gas detection monitoring instruments for worker protection used by industrial hygienists, first responders and homeland security personnel.
Water Analysis Instruments include meters, electrodes and solutions for the measurement of pH, ions, conductivity, dissolved oxygen, turbidity and other key parameters in the lab and production line. Based upon electrochemical and optical sensing technologies, these products are used in the food and beverage industry, chemical and pharmaceutical production, and for environmental compliance. Its process instrumentation is used for optimization and control in a range of process industries, and for detecting contamination in packaged materials and consumer goods. Its markets include power generation; paper and petrochemical; oil and gas; food and beverage, and pharmaceuticals, as well as water and wastewater municipalities; federal, state and local agencies; and general commercial and academic laboratories. Process Instruments help customers to monitor, control and optimize their processes. These instruments provide measurements; maintain regulatory compliance, and providing real-time direct and remote data collection, analysis and local control functions using a variety of technologies, including radiation; radar; ultrasonic and vibration measurement principles; gas chromatography, and mass spectrometry. Product Inspection products help customers in the food and beverage, pharmaceutical production and packaging industries to maintain safety and quality standards. Based on a variety of technologies, such as X-ray imaging and ultra-trace chemical detection, these products are used to inspect packaged goods for physical contaminants, validate fill quantities, or check for missing or broken parts on line and at high speeds.
The Company’s biosciences offerings include instruments and consumables that help customers conduct scientific research, discover and produce new drugs, and diagnose disease. These products fall into three main categories: life science research, global chemicals and bioprocess production. Life Science Research products enable customers to understand biological processes and the basis of human diseases and shorten the drug discovery and development process. It includes instruments, reagents, consumables and other products for molecular, protein and cell biology applications. The portfolio includes reagents and kits for protein analysis and detection; restriction and modifying enzymes, nucleotides and other molecular biology reagents; RNA-interference reagents and other gene-modulation products; polymerase chain reaction (PCR)/quantitative PCR (qPCR) reagents, instruments and plastic consumables; automated imaging instruments, and software and reagents for high-content analysis of cells and tissues.
Global Chemicals comprise a range of chemicals, solvents and reagents supporting virtually every laboratory application from research to discovery and development, to manufacturing. The portfolio includes organic chemicals used to synthesize new materials; essential laboratory chemicals used by scientists to purify, extract, separate, identify and manufacture products; bioreagents used in many different applications, from cell growth to detailed protein analysis; and chemical building blocks, reactive intermediates and screening libraries used to accelerate drug discovery. The Company also provides bulk volumes of many products for scale-up from research to development. BioProcess Production products include flexible, single-use bioprocess containers and bioprocessing systems as well as cell-culture media (including serum-free and protein-free media), sera and process liquids for the production of animal and human viral vaccines, monoclonal antibodies, protein-based therapeutics and products for wound healing. These products have been specifically qualified for bioscience applications in the biopharmaceutical, biotechnology and diagnostic industries.
Specialty Diagnostics Segment
The Company’s Specialty Diagnostics Segment offers a range of diagnostic test kits, reagents, culture media, instruments and associated products in order to serve customers in healthcare, clinical, pharmaceutical, industrial, and food safety laboratories. The segment has five primary businesses: ImmunoDiagnostics, Clinical Diagnostics, Microbiology, Anatomical Pathology and its Healthcare Market Customer Channel. Its immunodiagnostics offerings include developing, manufacturing and marketing complete blood-test systems to support the clinical diagnosis and monitoring of allergy, asthma and autoimmune diseases. Its in vitro allergy diagnostic tests utilize systems which provide for convenient and accurate allergy diagnoses on low and high-throughput automation. In addition, it offers antibody tests for approximately 20 chemical indications to help diagnose autoimmune diseases, such as rheumatoid arthritis, celiac disease, lupus and scleroderma. These allergy and autoimmunity product lines operate on a common instrument platform which supports both productivity and cost efficiencies in clinical laboratories around the world. Its products include ImmunoCAP for allergy and asthma tests and EliA for autoimmunity tests.
The Company’s clinical diagnostics products include an offering of liquid, ready-to-use and lyophilized immunodiagnostic reagent kits, calibrators, controls and calibration verification fluids. In particular, it provides products used for drugs-of-abuse testing; therapeutic drug monitoring, including immunosuppressant drug testing; thyroid hormone testing; serum toxicology; clinical chemistry; immunology; hematology; coagulation; glucose tolerance testing; monitoring and toxicology; first trimester screening; tumor markers testing, and biomarkers testing for sepsis, acute myocardial infarction and congestive heart failure. The Company also private label many of its immunoassay reagents and controls for major in vitro diagnostics companies through OEM arrangements. In many instances, it will work with customers or partners to develop new products and applications for their instrument platforms. The Company has developed menus for drugs-of-abuse immunoassays. It also offers a line of immunosuppressant drug immunoassays that can be used on a variety of clinical chemistry analyzers.
The Company’s clinical chemistry systems include analyzers and reagents to analyze and measure routine blood and urine chemistry, such as glucose and cholesterol; and advanced testing for specific proteins, therapeutic drug monitoring and drugs-of-abuse. Its diagnostic test range covers approximately 80 different validated methods. It also provides pre- and post-analytical automation for preparation of blood specimens before and after analysis, and specialty diagnostic tests based on patented biomarkers for sepsis, cardiovascular and pulmonary diseases, as well as intensive care treatments and prenatal screening. Its microbiology offerings include dehydrated and prepared culture media, collection and transport systems, diagnostic and rapid direct specimen tests, quality-control products and associated products for the microbiology laboratory. Its products help customers worldwide to diagnose infectious disease; determine appropriate antimicrobial therapy; implement infection control programs, and detect microbial contamination of their products or manufacturing facilities. Key clinical customers include hospitals, public health and reference laboratories, clinics and physician offices.
The Company’s anatomical pathology offerings include a portfolio of products primarily for cancer diagnosis and medical research in histology, cytology and hematology applications. These products include a range of instruments, consumables and reagents for specimen collection and transport, tissue preparation, staining and immunohistochemistry assays and controls. Reagent and consumable products include sample collection and preservation products used to ensure specimen integrity; tissue cassettes and reagents necessary for same-day, specimen processing; blades and paraffin used to section tissue; and a range of stains. Also included are a line of immunohistochemistry antibodies, detection systems, ancillaries and controls.
The Company also provides a range of anatomical pathology instruments, including cassette and slide labeling systems, which enable on-demand slide and cassette printing; tissue processors for same-day tissue-processing; superior reagent management and lab efficiency; embedding stations, microtomes and cryostats used to section tissue, and automated staining and cover slip systems used for primary and immunohistochemistry staining. In cytology, it offers low-speed centrifugation technology coupled with patented EZ cytofunnels to deposit a thin layer of cells onto a microscope slide to ensure better cell capture and better preservation of cell morphology. It manufactures flat-sheet glass to produce medical disposable products, such as microscope slides, plates, cover glass, and microarray substrates serving the medical, diagnostics, and scientific communities. It also offers specialized hydrophobic, adhesive, and fluorescent slides through coating techniques.
The Company’s Healthcare Market Customer Channel offerings include an array of consumables, diagnostic kits and reagents, equipment, instruments, solutions and services for hospitals, clinical laboratories, reference laboratories, physicians’ offices and other clinical testing facilities. These products are manufactured by Thermo Fisher and third parties. Healthcare Market products and solutions focus on the collection, transportation and analysis.
Laboratory Products and Services Segment
The Company’s Laboratory Products and Services segment offers thing needed for the laboratory. It serves the pharmaceutical, biotechnology, academic, government and other research and industrial markets, as well as the clinical laboratory through four businesses: Laboratory Equipment, Laboratory Consumables, Research and Safety Market Customer Channel, and BioPharma Services. The Company’s Laboratory Equipment solutions are used primarily by pharmaceutical companies for drug discovery and development and by biotechnology companies and universities for life science research to advance the prevention and cure of diseases. This offering consists of equipment, accessories, and services for sample preparation, storage and protection, and analysis, with product categories, including Sample Preparation and Preservation Equipment, Cold Storage Equipment, Centrifugation Products, Biological Safety Cabinets, Temperature Control Products, Laboratory Furniture and Other Laboratory Equipment.
Sample Preparation and Preservation Equipment protects its customers’ chemical and biological samples and supports the growth of cells and organisms in optimal conditions, such as temperature, carbon dioxide and humidity. This offering includes a comprehensive range of incubators and other related products. Cold Storage Equipment, such as its laboratory refrigerators and freezers, ultralow-temperature freezers and cryopreservation storage tanks maintain samples in a cold environment to protect them from degradation. These systems may be customized to accommodate specific equipment, allowing reactions (such as chromatography) to be run under low-temperature conditions. Centrifugation Products are used to separate biological matrices and inorganic materials. Its range includes microcentrifuges, which are used primarily for the purification of nucleic acids in the molecular biology laboratory; general use bench-top centrifuges for processing clinical samples, such as blood and urine, and its floor models, which are used for blood processing or in laboratories with high-throughput needs. Its super-speed and ultra-speed models are used for applications such as protein purification.
Biological Safety Cabinets enable technicians to handle samples without risk to themselves or their environment and without risk of cross-contamination of samples. These cabinets, equipped with filtered-air ventilation, controlled laminar flow and an ultraviolet source, can be used for tissue culture; handling of infectious samples; forensic analysis; bioterrorism research; and other applications. Temperature Control Products include heated bath circulators, immersion coolers, recirculating chillers, water baths, and dry baths in a range of sizes, temperatures and configurations for life science, analytical chemistry, manufacturing and quality-control applications. Laboratory Furniture includes workstations and fume hoods for either new construction or laboratory renovation. Its products include steel, wood and plastic laminate casework systems; adaptable furniture systems; chemical ventilation fume hoods; chemical storage cabinets; and various other laboratory fixtures and accessories. Other Laboratory Equipment includes water purification systems, shakers, vacuum concentrators, microbiological incubators, ovens, furnaces, hotplates, stirrers, stirring hotplates, and other related products.
The Company’s laboratory consumables products include plastic, glass and related equipment, which customers use every day to support their scientific research; drug discovery and development;, quality and process control; and clinical and basic research and development needs. It offers a range of surface technologies for different application needs, including applications with traditional stem cell and human stem cell lines. Its products include chamber slides, dishes, multidishes, flasks and gas permeable technologies. The Company also offers a line of serological pipettes and conical tubes to address cell-culture sample handling, as well as cell factories and roller bottles, which are widely used in the manufacture of vaccines and biotherapeutics.
Sample Preparation and Storage Products include a line of centrifugation consumables, as well as vials and organization systems for ultralow temperature and cryogenic storage, with specific products designed for low protein binding and low deoxyribonucleic acid (DNA) binding. It also offers containers for packaging life science and diagnostic reagents as well for the storage and transport of bulk intermediates and active pharmaceutical ingredients. Liquid Handling Products include a offering of laboratory pipette tips and a complementary range of handheld and automated pipetting systems, supporting low- through high-throughput activity. Detection Instruments include microplate readers, washers, purification systems, and PCR and qPCR instruments. Specialty Products and Services include a selection of clinical specimen collection, drug-of-abuse collection kits and environmental and food-safety glass and plastic vials, bottles and containers. It is engaged in the manufacture of plastic transfer pipettes and general purpose clinical laboratory consumables. It also offers containers for breast milk collection, storage and feeding primarily used in neo-natal units and by lactation specialists. In addition, it provide OEM and custom kit assembly services for clinical and drugs-of-abuse test kits.
The Company’s Research and Safety Market Customer Channel serves academic, pharmaceutical, biotechnology, government, industrial and healthcare customers through its Fisher Scientific, Fisher Science Education and Cole-Parmer offerings. Its channel offers a mix of products that are manufactured by Thermo Fisher, by third parties for the Company on a private-label basis, and by third parties under their brand but offered for sale exclusively through the Compa. Fisher Science Education offerings include science-related educational and laboratory products for the K-12 and secondary education market. Cole-Parmer offerings include a variety of laboratory and industrial fluid-handling products, instrumentation, equipment, and supplies for the industrial, government, academic, biotechnology, pharmaceutical and healthcare markets. In addition to its product offerings, it offers a variety of specialized services to its customers through oits Unity Lab Services team, including training, equipment servicing, and dedicated logistics personnel who manage inventory and provide desktop delivery, coordinate instrument calibration and service, provide on-site customer service and deliver other services. By providing these services, it enables its customers to focus on their core research and business activities.
The Company’s BioPharma Services offerings include global services for pharmaceutical and biotechnology companies engaged in clinical trials, including specialized packaging; over-encapsulation; multi-lingual and specialized labeling and distribution for phase I through phase IV clinical trials; biological-specimen management; specialty pharmaceutical logistics; and clinical supply-chain management. Thermo Fisher’s biorepository business provides temperature-controlled repository services for pharmaceutical, biotechnology, university, government, clinical and blood-processing customers. Its biorepository services business stores pharmacological and biospecimen samples at commercial sites. Additional services include inventory management, validation, business continuity, and repository management and transportation capabilities, resulting in a complete cold chain sample management solution.
Thermo Fisher Scientific Inc
81 WYMAN ST,
PO Box 9046
WALTHAM MA 02451
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