Volkswagen plays down hopes of quick answers over emissions cheating

WOLFSBURG, Germany - Volkswagen said on Wednesday it would take time to get to the bottom of its rigging of diesel emissions tests, hours before the carmaker is due to give updates on its findings to German regulators and U.S. lawmakers.

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DNA research deployed in war on cancer scoops Nobel prize

Three scientists from Sweden, the United States and Turkey won the 2015 Nobel Prize for Chemistry on Wednesday for working out how cells repair damaged DNA, providing new ammunition in the war on cancer.

Science, Turkey 11:22am EDT

SABMiller rejects AB InBev's $104 billion takeover approach

BRUSSELS - SABMiller , the world's second largest brewer, has promptly rejected an improved offer from bigger rival Anheuser-Busch InBev , saying on Wednesday that its 68 billion-pound ($104 billion) valuation was insufficient.

10:00am EDT

Russia backs Syrian forces in major assault on insurgents

BEIRUT - Russia and Syria carried out what appeared to be the first major coordinated assaults on Syrian insurgents on Wednesday and Moscow said its warships fired 26 missiles at them from the Caspian Sea, a sign of its new military reach. | Video

Hopes of survival fade for missing U.S. ship crew as search goes on

MIAMI - The U.S. Coast Guard resumed a search-and-rescue effort for a U.S. cargo ship on Wednesday, but hopes for the mostly American crew were fading six days after it sank in the Bahamas after running into Hurricane Joaquin.

10:36am EDT

Iran's supreme leader bans negotiations with the United States

DUBAI - Iran's Supreme Leader Ayatollah Ali Khamenei on Wednesday banned any further negotiations between Iran and the United States, putting the brakes on moderates hoping to end Iran's isolation after reaching a nuclear deal with world powers in July.

World, Davos, Russia 8:56am EDT

Two missing as floodwaters persist in South Carolina

COLUMBIA, S.C. - Residents in flood-ravaged South Carolina remained on alert Wednesday for more inundation from swollen rivers and vulnerable dams, while rescuers in one of the hardest hit areas searched for two people missing after a truck was submerged by water.