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Skin-to-stem cells for heart failure patients

Tuesday, May 22, 2012 - 00:06

May 22 - Scientists have for the first time succeeded in taking skin cells from patients with heart failure and transforming them into healthy, beating heart tissue that could one day be used to treat the condition. This video shows beating human heart tissue derived from human induced pluripotent stem cells. Rough Cut (no reporter narration).

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This video was provided by Lior Gepstein from the Technion-Israel Institute of Technology, who led the research. Gepstein's team took skin cells from two men with heart failure - aged 51 and 61 - and transformed them by adding three genes and then a small molecule called valproic acid to the cell nucleus. They found that the resulting stem cells were able to differentiate to become heart muscle cells, or cardiomyocytes. The team was then able to make the cardiomyocytes develop into heart muscle tissue, which they grew in a laboratory dish together with existing cardiac tissue. Within 24 to 48 hours the two types of tissue were beating together.

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Skin-to-stem cells for heart failure patients

Tuesday, May 22, 2012 - 00:06