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* FTSE 100 down 0.5%, FTSE 250 off 0.1%
June 24 (Reuters) - London stocks retreated on Wednesday as a spike in novel coronavirus cases across the globe compounded fears of a second wave of the pandemic, while builder Crest Nicholson tumbled after issuing a grim forecast for the year.
The homebuilder fell 2.9% to the bottom of the FTSE 250 as it posted a first-half pretax loss and said it expected annual adjusted pretax profit to fall around 60% to 70% due to coronavirus-led disruptions.
The blue-chip FTSE 100 was down 0.5% and the domestically focussed FTSE 250 0.1%, with financial, consumer staple and industrial stocks among the biggest drags.
A day after Prime Minister Boris Johnson further relaxed a coronavirus-induced lockdown, top medics warned British political parties that local flare-ups of the new coronavirus are likely and a second wave is a real risk.
In a bright spot, Mr Kipling cakes maker Premier Foods Plc rose 2% after forecasting revenue and trading profit for the new year to be above current estimates. (Reporting by Shashank Nayar and Sagarika Jaisinghani in Bengaluru; editing by Uttaresh.V)