There are no treatments approved for COVID-19, the respiratory illness caused by the coronavirus, and researchers are rushing to repurpose existing therapies such as nitric oxide-releasing drug INOmax.
Mallinckrodt said it would support and provide INOmax for a clinical study at Massachusetts General Hospital that would assess the effectiveness of inhaled nitric oxide in reversing abnormally low oxygen levels in the blood of COVID-19 patients with severe lung complications.
Over 170 hospitals in the United States have reported using INOmax to treat lung complications in COVID-19 patients, according to the company.
Earlier this month, the company received approval from Canada’s health regulator to conduct a clinical study, in collaboration with Novoteris LLC, to test inhaled nitric oxide therapy in COVID-19 patients. The companies expect to start enrollment in the coming days.
Mallinckrodt has also said it was working with the U.S. Food & Drug Administration on the possibility of making INOmax available to COVID-19 patients in the country.
The company markets INOmax in the United States for the treatment of respiratory failure associated with pulmonary hypertension, a condition of increased blood pressure within the arteries of the lungs.
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