Roche, Lilly drugs fail to halt gene-driven Alzheimer's disease

ZURICH (Reuters) - Experimental drugs from Roche and Eli Lilly failed to halt Alzheimer’s disease in their latest test, the companies said on Monday, in a blow to people whose genes make them particularly vulnerable to the illness.

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Pursuit of an Alzheimer’s remedy, which would inevitably reap drugmakers billions of dollars, has been marked by more than 100 failures, although researchers still hope to tame a condition that affects nearly 6 million Americans, more than 40 million people worldwide, and which is growing more prevalent.

The study of Roche’s gantenerumab and Eli Lilly’s solanezumab spearheaded by Washington University in St. Louis focused on rare autosomal dominant Alzheimer’s disease, which is caused by gene mutations that follow generations of families.

Those afflicted often develop Alzheimer’s disease before the age of 60 and have a 50% chance of passing the mutation on.

By targeting this group, scientists had hoped the medicines would arrest their cognitive decline. Years after the trial began, however, they concluded the drugs were not working.

“We are very grateful to all those involved in this study and hope the data can further contribute to the science and collective understanding of this complex disease,” Roche’s Chief Medical Officer Levi Garraway, said in a statement.

Like many other Alzheimer’s drug prospects, gantenerumab and solanezumab are designed to neutralize beta-amyloid plaques seen as a driver behind brain cell death.

Garraway said a pair of separate Roche studies of gantenerumab against a form of Alzheimer’s disease not directly caused by gene mutations would continue. It is due to produce results in 2022.

Roche is also testing gantenerumab in humans as part of its work with a ‘brain shuttle’ technology it hopes boosts penetration into the brain, where the drug is needed.

“At this time, Lilly does not plan to pursue a submission for solanezumab in people with dominantly inherited Alzheimer’s disease,” the company said in a statement.

Lilly said the study’s outcome will not impede its separate solanezumab study in asymptomatic Alzheimer’s disease.


These failures mark just the latest disappointments with gantenerumab and solanezumab.

For Roche, dosing of people thought to be in the early, or prodromal, stages of the disease was halted in 2014. For Eli Lilly, solanezumab has missed the mark in several studies, including a trial against mild Alzheimer’s disease that the Indiana-based company announced had failed in 2016.

Washington University professor Ronald Bateman, who led the latest trial, said its emerging insights include that brain changes as Alzheimer’s progresses are much the same in people with inherited, early-onset and late-onset disease.

“Ongoing and continued research and trials will bring us closer to our goal to stop Alzheimer’s,” Bateman said on the university’s website. “We will continue until we are successful.”

Reporting by John Miller; Editing by Thomas Seythal, Kim Coghill and Alexander Smith