February 22, 2018 / 12:26 PM / in 4 months

Sangamo in $3 billion gene-editing deal with Gilead

(Reuters) - U.S. drugmaker Gilead Sciences Inc will use Sangamo Therapeutics Inc’s gene-editing technology to develop cancer treatments in a deal potentially worth about $3 billion to Sangamo, the companies said on Thursday.

FILE PHOTO - The logo of Gilead Sciences Inc is pictured during a news conference in New Delhi September 15, 2014. Picture taken September 15, 2014. REUTERS/Anindito Mukherjee

The deal is the latest by a major drugmaker looking to develop lucrative gene therapies that have the potential to treat ailments by directly targeting disease-causing genes.

Shares of California biotech firm Sangamo jumped more than 20 percent to a 17-year high of $27.30 on Thursday morning.

“These are indeed exciting times in the field of genome-editing and gene therapy,” Sangamo Chief Executive Officer Sandy Macrae said on a call with analysts.

In December, Luxturna, a treatment for a rare disease that causes blindness, became the first gene therapy for an inherited disease to get U.S. regulatory approval.

The treatment, developed by Philadelphia-based Spark Therapeutics Inc, is expected to be priced at $850,000.

Gilead subsidiary Kite Pharma will use Sangamo’s platform to target a class of proteins called zinc finger nucleases in order to edit the human genome, helping develop therapies for cancer.

Sangamo will receive $150 million upfront and is eligible for up to $3.01 billion in future payments tied to regulatory and other milestones.

Gilead snapped up Kite Pharma in a $12 billion deal last year as a way to get access to an emerging class of cancer immunotherapies called CAR-T and to offset slowing sales of its hepatitis C medicines.

Other firms specializing in CAR-T such as Juno Therapeutics have signed deals to use another kind of gene-editing technology called CRISPR.

Gilead said earlier this month it would pursue collaborations with companies for gene-editing technology.

“(Gilead) scoured the field,” said Curt Herberts, Sangamo’s chief business officer.

Companies with gene-editing platforms including Editas Medicine and CRISPR Therapeutics saw their shares jump after Gilead signaled interest in the technology.

Reporting by Manas Mishra in Bengaluru; Editing by Savio D'Souza and Sai Sachin Ravikumar

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