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Vertex Pharmaceuticals Inc (VRTX.O)

VRTX.O on Nasdaq

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Latest Key Developments (Source: Significant Developments)

Vertex to acquire CTP-656 from Concert Pharmaceuticals
Monday, 6 Mar 2017 07:00am EST 

Vertex Pharmaceuticals Inc :Vertex to acquire CTP-656 from Concert Pharmaceuticals for the treatment of cystic fibrosis.  Full Article

Vertex Pharmaceuticals Q4 earnings per share $0.13
Wednesday, 25 Jan 2017 04:01pm EST 

Vertex Pharmaceuticals Inc - : Vertex reports full-year and fourth-quarter 2016 financial results . Q4 non-gaap earnings per share $0.35 . Q4 gaap earnings per share $0.13 . Reiterates 2017 financial guidance for orkambi product revenues of $1.1 to $1.3 billion and kalydeco product revenues of $690 to $710 million . Q4 earnings per share view $0.29 -- Thomson Reuters I/B/E/S . Company also reiterated guidance for its 2017 combined non-gaap research and development and SG&A expenses . Net product revenues from orkambi were $979.6 million compared to $350.7 million for 2015 . Net product revenues from kalydeco were $703.4 million compared to $631.7 million for 2015 . Expects that its 2017 combined gaap research and development and SG&A expenses will be in range of $1.55 to $1.70 billion .Qtrly total revenues $458.7 million $417.9 million.  Full Article

Vertex Pharmaceuticals appoints Ian Smith COO and CFO
Friday, 2 Dec 2016 09:21am EST 

Vertex Pharmaceuticals Inc : Vertex Pharmaceuticals -effective January 1, 2017, have appointed Ian Smith EVP - chief operating officer and chief financial officer . On Nov 30, term of CEO Jeffrey Leiden's employment agreement was extended through March 31, 2020 .Aslo, Leiden's cash severance benefit was reduced from 200 pct and target bonus to 100 pct of sum of base salary.  Full Article

Vertex Pharma: Amended and expanded agreement with Cystic Fibrosis Foundation Therapeutics
Friday, 14 Oct 2016 06:38am EDT 

Vertex Pharmaceuticals Inc : Vertex Pharma - on oct 13 amended and expanded research, development and commercialization agreement with cystic fibrosis foundation therapeutics inc . Vertex Pharma - amendment provides for upfront program award from cfft to us of $75.0 million,development funding from cfft to us of upto $6.0 million annually . Vertex Pharmaceuticals Inc- pursuant to amendment , co will continue to pay royalties ranging from low single digits to mid-single digits .Vertex Pharma-entered into data license deal with Cystic Fibrosis Foundation, co will pay for continuing access to data from CFF's patient registry.  Full Article

Vertex enrollment complete in Phase 3 study in people with two copies of F508DEL mutation
Monday, 15 Aug 2016 04:05pm EDT 

Vertex : Provides update on ongoing phase 3 program For VX-661 in combination with ivacaftor for the treatment of cystic fibrosis . Enrollment complete in phase 3 study in people with two copies of F508DEL mutation . Enrollment expected to be completed in September in phase 3 study in people with one F508DEL mutation, one residual function mutation .Plans to submit new drug application (NDA) to FDA for vx-661 in combination with ivacaftor in second half of 2017.  Full Article

Vertex Pharmaceuticals says reiterates 2016 guidance
Wednesday, 27 Jul 2016 04:16pm EDT 

Vertex Pharmaceuticals Inc : Vertex pharmaceuticals inc says reiterates 2016 guidance for orkambi product revenues of $1.0 to $1.1 billion . Gaap research and development and sg&a expenses . Vertex reports second quarter 2016 financial results . Q2 non-gaap earnings per share $0.24 . Q2 gaap loss per share $0.26 . Q2 earnings per share view $0.21 -- Thomson Reuters I/B/E/S .Vertex pharmaceuticals inc says reiterates 2016 guidance for kalydeco product revenues of $685 to $705 million.  Full Article

Vertex Pharmaceuticals and Moderna collaborate to discover and develop MRNA Therapeutics for cystic fibrosis
Wednesday, 6 Jul 2016 08:14am EDT 

Vertex Pharmaceuticals Inc : Vertex and Moderna establish exclusive collaboration to discover and develop mrna therapeutics(tm) for cystic fibrosis . Vertex will also pay Moderna future development and regulatory milestones of up to $275 million . Vertex Pharmaceuticals says $275 million payment, including $220 million in reimbursement milestones, as well as tiered royalty payments on future sales . Vertex Pharmaceuticals Inc says Moderna to receive $40 million upfront, made up of a $20 million cash payment and a $20 million convertible note investment . Vertex and Moderna will conduct exclusive research, development and commercialization activities to advance mrna therapeutics . Will lead all preclinical, development and commercialization activities associated with advancement of mrna therapeutics .Will fund all expenses related to collaboration.  Full Article

Vertex Pharma says target review date of Sept. 30 set for FDA's decision on application
Tuesday, 31 May 2016 07:58am EDT 

Vertex Pharmaceuticals Inc : Target review date of september 30, 2016 set for fda's decision on application .u.s. Fda accepts for priority review supplemental new drug application for the use of orkambi® (lumacaftor/ivacaftor) in children with cystic fibrosis ages 6 to 11 who have two copies of the f508del mutation.  Full Article

Spero Therapeutics to acquire worldwide rights to Vertex's VXC-486/VXC-100
Wednesday, 25 May 2016 08:00am EDT 

Spero Therapeutics LLC : Has entered into an agreement with Vertex Pharmaceuticals . Deal to acquire worldwide rights to VXC-486/VXC-100 and a portfolio of innovative antibacterial compounds . Under terms of agreement, Spero will make an upfront payment to Vertex for portfolio rights . Under terms of agreement, Spero will assume responsibility for drug development and bringing compounds to market .Vertex will be eligible to get future devpt,commercial milestones, royalties on any therapeutic products resulting from agreement.  Full Article

Vertex receives Australian approval for Orkambi
Tuesday, 8 Mar 2016 03:50pm EST 

Vertex Pharmaceuticals Inc:Receives Australian approval for Orkambi® (lumacaftor/ivacaftor), the first medicine to treat the underlying cause of cystic fibrosis in people ages 12 and older with two copies of the f508del mutation.Says Therapeutic Goods Administration (TGA) of Australia has approved Orkamb.  Full Article

BRIEF-Vertex Announces Positive Results From Open-Label Phase 3 Study Of KALYDECO(ivacaftor)

* VERTEX ANNOUNCES POSITIVE RESULTS FROM OPEN-LABEL PHASE 3 STUDY OF KALYDECO® (IVACAFTOR) IN CHILDREN WITH CYSTIC FIBROSIS AGES 1 TO 2 YEARS